Zonisamide makes you tired

Zonegran®

Zonegran capsules of 100 mg contain a yellow color called sunset yellow (E110). This azo dye can cause allergic reactions.

You should not take Zonegran

If you are allergic (hypersensitive) to zonisamide or any of the other ingredients of Zonegran.

If you are pregnant, think you may be pregnant or if you are breastfeeding.

If you have moderate to severe hepatic insufficiency.

If you have moderate to severe kidney failure.


This medicine can impair your ability to react, drive and use tools or machines!

Zonegran can cause drowsiness and tiredness, especially at higher doses (300-500 mg / day). Double vision has been reported frequently.

You should not drive or use machines until you have gained enough experience with Zonegran to be sure that the medicine does not affect your performance.

Patients who are hypersensitive to azo dyes, acetylsalicylic acid, rheumatism and pain relievers (prostaglandin inhibitors) should not take Zonegran capsules of 100 mg.

Take special care when taking Zonegran

If you are younger than 18 years as the use of Zonegran is not recommended for this age group.

If you are a woman of childbearing potential. You must use appropriate contraception while you are taking Zonegran and for up to one month after you stop taking Zonegran.

If you have an unexplained rash as it could develop into a more severe rash or skin peeling. Contact your doctor immediately as this can very rarely become serious.

If you are an elderly patient, as there is limited information about the use of Zonegran in this age group and the dose of your medicine may need to be adjusted and you may be more likely to develop an allergic reaction or a serious rash when using Zonegran take (see “What side effects can Zonegran have?”).

If you have liver problems as there is limited information on the use of Zonegran in these patients and the dose of your medicine may need to be changed or increased more slowly.

If you have kidney problems, as there is limited information on the use of Zonegran in this population and the dose of your medicine may need to be changed or increased more slowly.

If you suddenly have pain in your back or epigastric region, pain when urinating or blood in the urine, as these could be signs of kidney stones Zonegran can promote the formation of kidney stones. In addition to familial predisposition, risk factors for kidney stone formation are previously occurring kidney stones and increased excretion of calcium in the urine or the simultaneous use of other drugs that promote kidney stone formation. It is very important to ensure that you drink enough water while you are taking Zonegran to reduce this risk.

If you notice decreased sweating; this can lead to heat stroke, which may necessitate admission to hospital. Decreased sweating and an increase in body temperature occur especially when the ambient temperature is increased. Sports activities should be avoided when the ambient temperature is high. Make sure you drink enough water.

If you have lost a lot of weight or weigh less than 40 kg. Tell your doctor as this may need to be monitored.

If you are unusually tired or have had a sore throat for a few days, or notice that you bruise easily. Contact your doctor or health care professional as this may be a sign that you have a blood system disorder.

If you have headache, drowsiness, shortness of breath and loss of appetite, as these could be signs of low levels of bicarbonate in your blood and should be monitored and treated by your doctor.

If you have muscle pain or weakness. Inform your doctor.

If you have depression and / or have thoughts of harming or killing yourself. A small number of people being treated with anti-epileptic drugs such as Zonegran have had thoughts of harming or killing themselves.

When you stop your treatment. Follow your doctor's instructions for gradually reducing the dose of Zonegran.

Please also contact your doctor if these warnings have applied to you in the past.

Zonegran belongs to a group of medicines (sulphonamides) that can cause serious allergic reactions, serious skin rashes and blood disorders which, in extremely rare cases, can be very dangerous (life-threatening).

Inform your doctor or pharmacist if you suffer from other illnesses, have allergies or are taking or applying other medicines (including those you have bought yourself!).

The effects of zonisamide can be reduced by other medicines you are taking. These include medicines used to treat epilepsy such as phenytoin, carbamazepine and phenobarbital. In this case, your dose of Zonegran may need to be adjusted.


Women of childbearing potential must use appropriate contraception during treatment with Zonegran and for up to one month after stopping Zonegran.

If you are pregnant, think you may be pregnant, or plan to become pregnant, tell your doctor or health care professional. You should only use Zonegran during pregnancy if your doctor tells you to. Research has shown that children of women on anti-epileptic drug therapy have an increased risk of congenital malformations. However, under no circumstances should you stop Zonegran treatment on your own.

If you are taking Zonegran and for one month after you stop using Zonegran, you should not breast-feed.